方法：本研究共纳入507例IIM成年日本患者（445例DM，62例PM），收集其临床数据及血清标本。同时选取11例JDM患者，108例系统性红斑狼疮患者，433例系统性硬化症患者及124例特发性肺纤维化患者作为对照。利用多克隆抗-NXP2抗体应用免疫沉淀及蛋白印迹法测定血清中抗-NXP2抗体水平。

　　结果：7例成人DM患者（1.6%）及1例成人PM患者（1.6%）呈抗-NXP2抗体阳性。除了2例JDM患者抗-NXP2抗体阳性外，其余疾病对照均无此抗体阳性。在8例成人IIM患者中，3例在诊断IIM3年内发生恶性肿瘤。另有1例DM患者在诊断时同时伴有转移瘤。所有上述恶性肿瘤均处于进展期（IIIb-IV期）。

　　结论：虽然阳性率低于幼年型炎性肌病，但抗-NXP2抗体仍可见于成年IIM。抗-NXP2抗体可能与成人IIM合并恶性肿瘤相关。

　　附原文：OBJECTIVES: Myositis-specific autoantibodies (MSAs) are useful tools for identifying clinically homogeneous subsets and predicting prognosis of patients with idiopathic inflammatory myopathies (IIM) including polymyositis (PM) and dermatomyositis (DM). Recent studies have shown that anti-NXP2 antibody (Ab) is a major MSA in juvenile dermatomyositis (JDM). In this study the frequencies and clinical associations of anti-NXP2 Ab were evaluated in adult patients with IIM.METHODS: Clinical data and serum samples were collected from 507 adult Japanese patients with IIM (445 with DM and 62 with PM). Eleven patients with JDM, 108 with systemic lupus erythematosus, 433 with systemic sclerosis and 124 with idiopathic pulmonary fibrosis were assessed as disease controls. Serum was examined for anti-NXP2 Ab by immunoprecipitation and western blotting using polyclonal anti-NXP2 Ab.RESULTS: Seven patients (1.6%) with adult DM and one (1.6%) with adult PM were positive for anti-NXP2 Ab. Except for two patients with JDM, none of the disease controls were positive for this autoantibody. Among eight adult patients with IIM, three had internal malignancies within 3 years of diagnosis of IIM. Another patient with DM also had a metastatic cancer at the diagnosis. All of the carcinomas were at an advanced stage (stage IIIb-IV).CONCLUSIONS: While less common than in juvenile IIM, anti-NXP2 Ab was found in adult IIM. Anti-NXP2 Ab may be associated with adult IIM with malignancy.

　　引自：Ichimura Y, Matsushita T, Hamaguchi Y et al. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. Ann Rheum Dis. 2012 May;71(5):710-3.